Drug interactions
Piroxicam + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Piroxicam and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion in volume-depleted patients. Taking piroxicam around the time of bowel preparation raises the risk of acute kidney injury.
What this interaction means in plain words
Piroxicam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from catharsis combined with NSAID-mediated inhibition of renal prostaglandins reduces glomerular perfusion.
What to do
Hold piroxicam during bowel preparation where feasible and ensure adequate hydration; check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Piroxicam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion in volume-depleted patients. Taking piroxicam around the time of bowel preparation raises the risk of acute kidney injury.
How serious is the interaction between Piroxicam and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold piroxicam during bowel preparation where feasible and ensure adequate hydration; check renal function and electrolytes in high-risk patients.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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