Drug interactions
Piroxicam + Sulfamethoxazole
Severity: Moderate
Piroxicam and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9 and may increase piroxicam exposure. Higher piroxicam levels could heighten gastrointestinal and renal toxicity, particularly with long-term use or reduced kidney function.
What this interaction means in plain words
Piroxicam and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfamethoxazole inhibition of CYP2C9-mediated piroxicam metabolism.
What to do
Use the lowest effective piroxicam dose and monitor renal function and signs of gastrointestinal bleeding, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Piroxicam and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole inhibits CYP2C9 and may increase piroxicam exposure. Higher piroxicam levels could heighten gastrointestinal and renal toxicity, particularly with long-term use or reduced kidney function.
How serious is the interaction between Piroxicam and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective piroxicam dose and monitor renal function and signs of gastrointestinal bleeding, particularly in older patients.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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