Drug interactions
Piroxicam + Sulfasalazine
Severity: Minor
Piroxicam and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine contains a salicylate moiety (5-ASA) and can cause blood dyscrasias, while piroxicam adds GI and renal risk. The combination may modestly increase GI bleeding risk and renal or potassium effects.
What this interaction means in plain words
Piroxicam and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Overlapping effects on platelet function, GI mucosa and renal prostaglandins; interaction is mostly additive and small.
What to do
Usually no change is needed; monitor for GI symptoms and check renal function and blood counts as per routine sulfasalazine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Sulfasalazine?
MediHelp rates the interaction as minor. Piroxicam and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine contains a salicylate moiety (5-ASA) and can cause blood dyscrasias, while piroxicam adds GI and renal risk. The combination may modestly increase GI bleeding risk and renal or potassium effects.
How serious is the interaction between Piroxicam and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; monitor for GI symptoms and check renal function and blood counts as per routine sulfasalazine monitoring.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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