Drug interactions
Piroxicam + Telmisartan-amlodipine
Severity: Moderate
Piroxicam and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may weaken the blood pressure control achieved with telmisartan. The combination can also reduce kidney function and increase potassium, with higher risk in the elderly and volume-depleted patients.
What this interaction means in plain words
Piroxicam and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory renal prostaglandins by the NSAID reduces renal perfusion and opposes ARB action, increasing risk of renal impairment and hyperkalemia.
What to do
Check blood pressure, serum creatinine and potassium after starting piroxicam and periodically thereafter. Use the shortest possible course or choose a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Piroxicam and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam may weaken the blood pressure control achieved with telmisartan. The combination can also reduce kidney function and increase potassium, with higher risk in the elderly and volume-depleted patients.
How serious is the interaction between Piroxicam and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, serum creatinine and potassium after starting piroxicam and periodically thereafter. Use the shortest possible course or choose a non-NSAID analgesic.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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