Drug interactions
Piroxicam + Tenofovir disoproxil
Severity: Moderate
Piroxicam and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as piroxicam can reduce renal blood flow and glomerular filtration, and tenofovir is itself associated with proximal tubular toxicity. Used together, particularly with high or repeated NSAID doses, they may raise the risk of acute kidney injury and increase tenofovir exposure.
What this interaction means in plain words
Piroxicam and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID-induced renal hemodynamic effects plus tenofovir tubular injury, with possible reduced renal elimination of tenofovir.
What to do
Prefer a non-NSAID analgesic such as paracetamol where feasible. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine, phosphate and urine protein.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Piroxicam and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as piroxicam can reduce renal blood flow and glomerular filtration, and tenofovir is itself associated with proximal tubular toxicity. Used together, particularly with high or repeated NSAID doses, they may raise the risk of acute kidney injury and increase tenofovir exposure.
How serious is the interaction between Piroxicam and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as paracetamol where feasible. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine, phosphate and urine protein.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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