Drug interactions
Piroxicam + Ticarcillin
Severity: Minor
Piroxicam and Ticarcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin is renally eliminated and can impair platelet function at high doses, while piroxicam also affects platelets and renal function. The combination may slightly increase bleeding risk, and reduced renal clearance could raise penicillin levels.
What this interaction means in plain words
Piroxicam and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive platelet effects and possible reduced renal clearance of the penicillin due to NSAID effects on renal function.
What to do
Monitor for bleeding and renal function, especially in patients receiving high-dose ticarcillin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Ticarcillin?
MediHelp rates the interaction as minor. Piroxicam and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticarcillin is renally eliminated and can impair platelet function at high doses, while piroxicam also affects platelets and renal function. The combination may slightly increase bleeding risk, and reduced renal clearance could raise penicillin levels.
How serious is the interaction between Piroxicam and Ticarcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function, especially in patients receiving high-dose ticarcillin.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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