Drug interactions
Piroxicam + Tobramycin inhaled
Severity: Moderate
Piroxicam and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low but measurable systemic absorption, which can be higher in renal impairment or with extensive airway disease. NSAIDs can reduce renal function and may increase aminoglycoside accumulation and nephrotoxicity.
What this interaction means in plain words
Piroxicam and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic potential, with NSAID-reduced renal clearance of tobramycin.
What to do
Monitor serum creatinine and, in patients at risk, tobramycin serum levels. Avoid NSAIDs in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Piroxicam and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled tobramycin has low but measurable systemic absorption, which can be higher in renal impairment or with extensive airway disease. NSAIDs can reduce renal function and may increase aminoglycoside accumulation and nephrotoxicity.
How serious is the interaction between Piroxicam and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and, in patients at risk, tobramycin serum levels. Avoid NSAIDs in patients with reduced renal function.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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