Drug interactions
Piroxicam + Venlafaxine
Severity: Moderate
Piroxicam and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine inhibits serotonin reuptake into platelets and combined with an NSAID increases the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Piroxicam and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin and aggregation from venlafaxine adds to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for bleeding and consider a proton pump inhibitor in higher-risk patients. Avoid long-term piroxicam where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Piroxicam with Venlafaxine?
MediHelp rates the interaction as moderate. Piroxicam and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine inhibits serotonin reuptake into platelets and combined with an NSAID increases the risk of gastrointestinal and other bleeding.
How serious is the interaction between Piroxicam and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider a proton pump inhibitor in higher-risk patients. Avoid long-term piroxicam where possible.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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