Drug interactions
Pirtobrutinib + Repaglinide
Severity: Moderate
Pirtobrutinib and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib inhibits CYP2C8 and may increase repaglinide levels, as repaglinide is partly cleared by this enzyme. This can enhance glucose lowering and cause hypoglycemia.
What this interaction means in plain words
Pirtobrutinib and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirtobrutinib belongs to Oncology; Repaglinide belongs to Endocrine.
Why it happens
Pirtobrutinib inhibits CYP2C8-mediated metabolism of repaglinide.
What to do
Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Pirtobrutinib with Repaglinide?
MediHelp rates the interaction as moderate. Pirtobrutinib and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib inhibits CYP2C8 and may increase repaglinide levels, as repaglinide is partly cleared by this enzyme. This can enhance glucose lowering and cause hypoglycemia.
How serious is the interaction between Pirtobrutinib and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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