Drug interactions
Pirtobrutinib + Topotecan
Severity: Moderate
Pirtobrutinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib inhibits BCRP, a transporter involved in topotecan absorption and elimination. Exposure to topotecan may rise, increasing the risk of myelosuppression.
What this interaction means in plain words
Pirtobrutinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirtobrutinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Pirtobrutinib inhibits BCRP-mediated efflux of topotecan.
What to do
Monitor complete blood counts and consider reducing the topotecan dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Pirtobrutinib with Topotecan?
MediHelp rates the interaction as moderate. Pirtobrutinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib inhibits BCRP, a transporter involved in topotecan absorption and elimination. Exposure to topotecan may rise, increasing the risk of myelosuppression.
How serious is the interaction between Pirtobrutinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and consider reducing the topotecan dose if toxicity appears.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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