Drug interactions
Pirtobrutinib + Warfarin
Severity: Moderate
Pirtobrutinib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib is a weak CYP3A4 inhibitor and may slightly raise exposure to warfarin's R-enantiomer. Pirtobrutinib may also impair platelet function and carries its own bleeding risk. Together these may raise the risk of bleeding.
What this interaction means in plain words
Pirtobrutinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirtobrutinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition reduces warfarin clearance, combined with additive bleeding risk from BTK inhibition.
What to do
Monitor INR closely when starting or stopping pirtobrutinib, and adjust warfarin dose as needed. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Pirtobrutinib with Warfarin?
MediHelp rates the interaction as moderate. Pirtobrutinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib is a weak CYP3A4 inhibitor and may slightly raise exposure to warfarin's R-enantiomer. Pirtobrutinib may also impair platelet function and carries its own bleeding risk. Together these may raise the risk of bleeding.
How serious is the interaction between Pirtobrutinib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely when starting or stopping pirtobrutinib, and adjust warfarin dose as needed. Monitor for bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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