Drug interactions
Pitavastatin + Rosiglitazone
Severity: Minor
Pitavastatin and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone may weakly inhibit OATP1B1, which could modestly raise pitavastatin concentrations. Clinically significant myopathy from this pairing has not been well documented and the effect is probably small.
What this interaction means in plain words
Pitavastatin and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pitavastatin belongs to Cardiovascular; Rosiglitazone belongs to Endocrine.
Why it happens
Possible weak inhibition of OATP1B1-mediated hepatic uptake of pitavastatin by rosiglitazone, supported mainly by in vitro data.
What to do
No routine dose change is needed. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Pitavastatin with Rosiglitazone?
MediHelp rates the interaction as minor. Pitavastatin and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rosiglitazone may weakly inhibit OATP1B1, which could modestly raise pitavastatin concentrations. Clinically significant myopathy from this pairing has not been well documented and the effect is probably small.
How serious is the interaction between Pitavastatin and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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