Drug interactions
Pitavastatin + Tacrolimus
Severity: Moderate
Pitavastatin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit OATP1B1 and can raise statin exposure. Transplant recipients often have additional risk factors for statin myopathy, so the combination deserves attention.
What this interaction means in plain words
Pitavastatin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitavastatin belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus may inhibit OATP1B1-mediated hepatic uptake of pitavastatin, increasing systemic exposure.
What to do
Start pitavastatin at a low dose and titrate cautiously. Monitor for myopathy symptoms and check creatine kinase if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Pitavastatin with Tacrolimus?
MediHelp rates the interaction as moderate. Pitavastatin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may inhibit OATP1B1 and can raise statin exposure. Transplant recipients often have additional risk factors for statin myopathy, so the combination deserves attention.
How serious is the interaction between Pitavastatin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pitavastatin at a low dose and titrate cautiously. Monitor for myopathy symptoms and check creatine kinase if they appear.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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