Drug interactions
Pitavastatin + Trofinetide
Severity: Moderate
Pitavastatin and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 in vitro and may increase pitavastatin concentrations. The higher exposure could heighten the risk of statin myopathy.
What this interaction means in plain words
Pitavastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitavastatin belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of OATP1B1/1B3 by trofinetide reduces hepatic uptake of pitavastatin.
What to do
Monitor for muscle pain and weakness and consider a lower pitavastatin dose. Select an alternative lipid-lowering agent if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pitavastatin and Trofinetide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Pitavastatin with Trofinetide?
MediHelp rates the interaction as moderate. Pitavastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 in vitro and may increase pitavastatin concentrations. The higher exposure could heighten the risk of statin myopathy.
How serious is the interaction between Pitavastatin and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain and weakness and consider a lower pitavastatin dose. Select an alternative lipid-lowering agent if toxicity occurs.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
