Drug interactions
Pitolisant + Sertraline
Severity: Moderate
Pitolisant and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so combining them may add to the risk of ventricular arrhythmia including torsades de pointes. Sertraline's effect on QT is modest, but the risk rises with other risk factors such as electrolyte disturbance or structural heart disease.
What this interaction means in plain words
Pitolisant and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitolisant belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization (QT interval).
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid the pair in patients with congenital long QT or other QT-prolonging drugs, and monitor ECG after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Sertraline?
MediHelp rates the interaction as moderate. Pitolisant and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, so combining them may add to the risk of ventricular arrhythmia including torsades de pointes. Sertraline's effect on QT is modest, but the risk rises with other risk factors such as electrolyte disturbance or structural heart disease.
How serious is the interaction between Pitolisant and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid the pair in patients with congenital long QT or other QT-prolonging drugs, and monitor ECG after initiation.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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