Drug interactions
Pitolisant + Terbinafine
Severity: Moderate
Pitolisant and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant is metabolized by CYP2D6 and CYP3A4, and strong CYP2D6 inhibition raises its levels. Higher exposure may cause QT prolongation, insomnia and anxiety.
What this interaction means in plain words
Pitolisant and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitolisant belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6, increasing pitolisant plasma concentrations.
What to do
Halve the pitolisant dose when terbinafine is started, or start at the reduced labeled dose, with a maximum of 17.8 mg daily; monitor ECG in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Terbinafine?
MediHelp rates the interaction as moderate. Pitolisant and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant is metabolized by CYP2D6 and CYP3A4, and strong CYP2D6 inhibition raises its levels. Higher exposure may cause QT prolongation, insomnia and anxiety.
How serious is the interaction between Pitolisant and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the pitolisant dose when terbinafine is started, or start at the reduced labeled dose, with a maximum of 17.8 mg daily; monitor ECG in at-risk patients.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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