Drug interactions
Pneumococcal vaccine 13-valent + Prednisolone
Severity: Minor
Pneumococcal vaccine 13-valent and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of corticosteroids may weaken the antibody response to inactivated vaccines. The 13-valent conjugate vaccine is non-live, so it is not contraindicated and remains recommended, although the response may be reduced.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Prednisolone belongs to Endocrine.
Why it happens
Corticosteroid immunosuppression blunts the immune response to vaccination.
What to do
Vaccinate as indicated, preferably before starting prolonged high-dose steroids when possible. Do not withhold the vaccine because of steroid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Prednisolone?
MediHelp rates the interaction as minor. Pneumococcal vaccine 13-valent and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppressive doses of corticosteroids may weaken the antibody response to inactivated vaccines. The 13-valent conjugate vaccine is non-live, so it is not contraindicated and remains recommended, although the response may be reduced.
How serious is the interaction between Pneumococcal vaccine 13-valent and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated, preferably before starting prolonged high-dose steroids when possible. Do not withhold the vaccine because of steroid therapy.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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