Drug interactions
Pneumococcal vaccine 13-valent + Siponimod
Severity: Moderate
Pneumococcal vaccine 13-valent and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod reduces circulating lymphocytes and may blunt the antibody response to vaccination. The vaccine is inactivated, so it does not cause infection, but its protective effect may be diminished.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Siponimod belongs to Central Nervous System.
Why it happens
Siponimod-induced lymphocyte sequestration impairs the immune response to vaccination.
What to do
Where feasible, give the vaccine at least one week before starting siponimod, or at least four weeks after stopping it. If vaccinated during treatment, accept that the response may be reduced and consider checking titers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Siponimod?
MediHelp rates the interaction as moderate. Pneumococcal vaccine 13-valent and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod reduces circulating lymphocytes and may blunt the antibody response to vaccination. The vaccine is inactivated, so it does not cause infection, but its protective effect may be diminished.
How serious is the interaction between Pneumococcal vaccine 13-valent and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, give the vaccine at least one week before starting siponimod, or at least four weeks after stopping it. If vaccinated during treatment, accept that the response may be reduced and consider checking titers.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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