Drug interactions
Pneumococcal vaccine heptavalent + Sirolimus
Severity: Moderate
Pneumococcal vaccine heptavalent and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may blunt the antibody response to inactivated vaccines, so protection may be inadequate. The vaccine is non-live and is not unsafe in itself.
What this interaction means in plain words
Pneumococcal vaccine heptavalent and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus inhibits mTOR-dependent lymphocyte proliferation, reducing the immune response to vaccination.
What to do
Vaccinate ideally before starting immunosuppression or when dosing is lowest; do not withhold it. Consider checking antibody titers or giving booster doses where applicable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine heptavalent with Sirolimus?
MediHelp rates the interaction as moderate. Pneumococcal vaccine heptavalent and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may blunt the antibody response to inactivated vaccines, so protection may be inadequate. The vaccine is non-live and is not unsafe in itself.
How serious is the interaction between Pneumococcal vaccine heptavalent and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before starting immunosuppression or when dosing is lowest; do not withhold it. Consider checking antibody titers or giving booster doses where applicable.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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