Drug interactions
Pneumococcal vaccine polyvalent + Tacrolimus
Severity: Moderate
Pneumococcal vaccine polyvalent and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can reduce the antibody response to the polysaccharide pneumococcal vaccine. The vaccine is non-live, so it can be given, but protection may be incomplete.
What this interaction means in plain words
Pneumococcal vaccine polyvalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition dampens adaptive immune responses to vaccine antigens.
What to do
Follow the immunocompromised pneumococcal schedule, using a conjugate vaccine first where recommended. Do not interrupt tacrolimus for vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Pneumococcal vaccine polyvalent with Tacrolimus?
MediHelp rates the interaction as moderate. Pneumococcal vaccine polyvalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can reduce the antibody response to the polysaccharide pneumococcal vaccine. The vaccine is non-live, so it can be given, but protection may be incomplete.
How serious is the interaction between Pneumococcal vaccine polyvalent and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the immunocompromised pneumococcal schedule, using a conjugate vaccine first where recommended. Do not interrupt tacrolimus for vaccination.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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