Drug interactions
Poliovirus vaccine inactivated + Tacrolimus
Severity: Moderate
Poliovirus vaccine inactivated and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression with tacrolimus can blunt the antibody response to inactivated poliovirus vaccine, leaving the patient less protected. The vaccine is not live, so there is no added infection risk from it.
What this interaction means in plain words
Poliovirus vaccine inactivated and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tacrolimus inhibits calcineurin-dependent T-cell activation, which reduces the immune response to vaccination.
What to do
Vaccinate before starting immunosuppression when possible. If given during therapy, consider checking serologic response or revaccinating once immunosuppression is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Poliovirus vaccine inactivated with Tacrolimus?
MediHelp rates the interaction as moderate. Poliovirus vaccine inactivated and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression with tacrolimus can blunt the antibody response to inactivated poliovirus vaccine, leaving the patient less protected. The vaccine is not live, so there is no added infection risk from it.
How serious is the interaction between Poliovirus vaccine inactivated and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting immunosuppression when possible. If given during therapy, consider checking serologic response or revaccinating once immunosuppression is reduced.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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