Drug interactions
Ponatinib + Pravastatin
Severity: Moderate
Ponatinib and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may inhibit transporters involved in pravastatin disposition and raise its levels. Both drugs are also associated with adverse hepatic or muscle effects.
What this interaction means in plain words
Ponatinib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Pravastatin belongs to Cardiovascular.
Why it happens
Ponatinib inhibits P-glycoprotein and possibly OATP1B1, increasing pravastatin exposure.
What to do
Monitor for myalgia and check CK if symptoms occur; consider lowering the pravastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Pravastatin?
MediHelp rates the interaction as moderate. Ponatinib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib may inhibit transporters involved in pravastatin disposition and raise its levels. Both drugs are also associated with adverse hepatic or muscle effects.
How serious is the interaction between Ponatinib and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and check CK if symptoms occur; consider lowering the pravastatin dose.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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