Drug interactions
Ponatinib + Rosuvastatin
Severity: Moderate
Ponatinib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may increase rosuvastatin exposure by inhibiting transporters, potentially raising the risk of myopathy. Ponatinib itself can cause muscle toxicity and elevated creatine kinase, adding to concern.
What this interaction means in plain words
Ponatinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Ponatinib may inhibit BCRP and OATP1B1, decreasing rosuvastatin efflux and hepatic uptake.
What to do
Monitor for muscle pain and weakness and consider a lower rosuvastatin dose. Check creatine kinase if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Rosuvastatin?
MediHelp rates the interaction as moderate. Ponatinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib may increase rosuvastatin exposure by inhibiting transporters, potentially raising the risk of myopathy. Ponatinib itself can cause muscle toxicity and elevated creatine kinase, adding to concern.
How serious is the interaction between Ponatinib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain and weakness and consider a lower rosuvastatin dose. Check creatine kinase if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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