Drug interactions
Ponatinib + Tacrolimus
Severity: Moderate
Ponatinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein in vitro and may raise exposure to tacrolimus, a P-gp substrate with a narrow therapeutic index. Higher tacrolimus concentrations could cause nephrotoxicity, neurotoxicity and hyperglycemia. The clinical magnitude is not well characterized.
What this interaction means in plain words
Ponatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponatinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Ponatinib inhibits P-glycoprotein efflux, potentially reducing tacrolimus efflux and increasing its absorption and exposure.
What to do
Monitor tacrolimus trough concentrations and renal function when ponatinib is started or stopped. Adjust the tacrolimus dose to the target trough.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Tacrolimus?
MediHelp rates the interaction as moderate. Ponatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein in vitro and may raise exposure to tacrolimus, a P-gp substrate with a narrow therapeutic index. Higher tacrolimus concentrations could cause nephrotoxicity, neurotoxicity and hyperglycemia. The clinical magnitude is not well characterized.
How serious is the interaction between Ponatinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when ponatinib is started or stopped. Adjust the tacrolimus dose to the target trough.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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