Drug interactions
Potassium citrate-citric acid + Tacrolimus
Severity: Moderate
Potassium citrate-citric acid and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus commonly causes hyperkalemia by impairing renal potassium secretion, and potassium citrate adds to the load. Clinically important hyperkalemia may result, particularly in transplant recipients with reduced renal function.
What this interaction means in plain words
Potassium citrate-citric acid and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Potassium citrate-citric acid belongs to Gastrointestinal Tract; Tacrolimus belongs to Miscellaneous.
Why it happens
Calcineurin inhibition reduces aldosterone effect and distal tubular potassium secretion, compounding the supplemental potassium.
What to do
Monitor serum potassium and renal function frequently. Avoid unnecessary potassium supplementation and reduce or stop it if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Potassium citrate-citric acid
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Potassium citrate-citric acid with Tacrolimus?
MediHelp rates the interaction as moderate. Potassium citrate-citric acid and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus commonly causes hyperkalemia by impairing renal potassium secretion, and potassium citrate adds to the load. Clinically important hyperkalemia may result, particularly in transplant recipients with reduced renal function.
How serious is the interaction between Potassium citrate-citric acid and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function frequently. Avoid unnecessary potassium supplementation and reduce or stop it if potassium rises.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
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