Drug interactions
Pralatrexate + Tolmetin
Severity: Major
Pralatrexate and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can delay the elimination of pralatrexate and increase its exposure, raising the risk of mucositis, myelosuppression and other toxicities.
What this interaction means in plain words
Pralatrexate and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pralatrexate belongs to Oncology; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAIDs reduce renal blood flow and may compete for renal tubular secretion, decreasing pralatrexate clearance.
What to do
Avoid concurrent use if possible, or monitor closely for mucositis, blood counts and renal function and adjust the pralatrexate dose as indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Pralatrexate with Tolmetin?
MediHelp rates the interaction as major. Pralatrexate and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can delay the elimination of pralatrexate and increase its exposure, raising the risk of mucositis, myelosuppression and other toxicities.
How serious is the interaction between Pralatrexate and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible, or monitor closely for mucositis, blood counts and renal function and adjust the pralatrexate dose as indicated.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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