Drug interactions
Pralatrexate + Trastuzumab
Severity: Moderate
Pralatrexate and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab can add to the neutropenia seen with myelosuppressive chemotherapy, and pralatrexate itself causes bone marrow suppression and mucositis. Used together, the risk of neutropenia, febrile neutropenia and infection may be higher.
What this interaction means in plain words
Pralatrexate and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pralatrexate belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression; trastuzumab appears to increase chemotherapy-associated neutropenia through an incompletely understood mechanism.
What to do
Monitor complete blood counts regularly, and assess promptly for fever or signs of infection. Delay or reduce the pralatrexate dose according to its labeled hematologic criteria.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Other interactions of Trastuzumab
Frequently asked questions
Can I take Pralatrexate with Trastuzumab?
MediHelp rates the interaction as moderate. Pralatrexate and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab can add to the neutropenia seen with myelosuppressive chemotherapy, and pralatrexate itself causes bone marrow suppression and mucositis. Used together, the risk of neutropenia, febrile neutropenia and infection may be higher.
How serious is the interaction between Pralatrexate and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, and assess promptly for fever or signs of infection. Delay or reduce the pralatrexate dose according to its labeled hematologic criteria.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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