Drug interactions
Pralatrexate + Ublituximab
Severity: Moderate
Pralatrexate and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and pralatrexate is myelosuppressive and immunosuppressive, so together they may increase the risk of infections. The risk is additive and depends on dose and duration.
What this interaction means in plain words
Pralatrexate and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pralatrexate belongs to Oncology; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from B-cell depletion and antimetabolite-induced myelosuppression.
What to do
Monitor for signs of infection and blood counts, and consider infection prophylaxis according to local protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Other interactions of Ublituximab
Frequently asked questions
Can I take Pralatrexate with Ublituximab?
MediHelp rates the interaction as moderate. Pralatrexate and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and pralatrexate is myelosuppressive and immunosuppressive, so together they may increase the risk of infections. The risk is additive and depends on dose and duration.
How serious is the interaction between Pralatrexate and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and blood counts, and consider infection prophylaxis according to local protocols.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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