Drug interactions
Pralsetinib + Voriconazole
Severity: Major
Pralsetinib and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases pralsetinib exposure, which may worsen hepatotoxicity, hypertension, pneumonitis and hemorrhage.
What this interaction means in plain words
Pralsetinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pralsetinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by voriconazole decreases pralsetinib metabolism.
What to do
Avoid if possible; otherwise reduce pralsetinib dose per labeling and monitor liver tests and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Pralsetinib
Frequently asked questions
Can I take Pralsetinib with Voriconazole?
MediHelp rates the interaction as major. Pralsetinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole increases pralsetinib exposure, which may worsen hepatotoxicity, hypertension, pneumonitis and hemorrhage.
How serious is the interaction between Pralsetinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce pralsetinib dose per labeling and monitor liver tests and blood pressure.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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