Drug interactions
Pramipexole + Promethazine
Severity: Moderate
Pramipexole and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is a phenothiazine with central dopamine D2 antagonist activity, which can oppose the effect of dopamine agonists. This may worsen motor symptoms in Parkinson disease or reduce benefit in restless legs syndrome.
What this interaction means in plain words
Pramipexole and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pramipexole belongs to Cardiovascular; Promethazine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at central dopamine D2 receptors.
What to do
Avoid promethazine in patients with Parkinson disease and use a non-dopamine-blocking antiemetic such as domperidone or ondansetron. Monitor motor symptoms if use cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Pramipexole with Promethazine?
MediHelp rates the interaction as moderate. Pramipexole and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine is a phenothiazine with central dopamine D2 antagonist activity, which can oppose the effect of dopamine agonists. This may worsen motor symptoms in Parkinson disease or reduce benefit in restless legs syndrome.
How serious is the interaction between Pramipexole and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid promethazine in patients with Parkinson disease and use a non-dopamine-blocking antiemetic such as domperidone or ondansetron. Monitor motor symptoms if use cannot be avoided.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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