Drug interactions
Pramipexole + Quinine
Severity: Minor
Pramipexole and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pramipexole is a cationic drug eliminated by renal tubular secretion, and quinine may compete for this pathway and increase pramipexole levels. This could increase dopaminergic effects such as dizziness, somnolence or hallucinations.
What this interaction means in plain words
Pramipexole and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pramipexole belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular cationic secretion (OCT2/MATE).
What to do
Monitor for pramipexole adverse effects and reduce the dose if somnolence, dizziness or hallucinations occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Pramipexole with Quinine?
MediHelp rates the interaction as minor. Pramipexole and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pramipexole is a cationic drug eliminated by renal tubular secretion, and quinine may compete for this pathway and increase pramipexole levels. This could increase dopaminergic effects such as dizziness, somnolence or hallucinations.
How serious is the interaction between Pramipexole and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pramipexole adverse effects and reduce the dose if somnolence, dizziness or hallucinations occur.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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