Drug interactions
Pramipexole + Zuranolone
Severity: Moderate
Pramipexole and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and somnolence. Combined use may increase CNS depression and impair driving and psychomotor performance.
What this interaction means in plain words
Pramipexole and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pramipexole belongs to Cardiovascular; Zuranolone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Consider reducing the zuranolone dose if sedation occurs. Advise patients not to drive for at least 12 hours after zuranolone and monitor for excessive sleepiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Pramipexole with Zuranolone?
MediHelp rates the interaction as moderate. Pramipexole and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and somnolence. Combined use may increase CNS depression and impair driving and psychomotor performance.
How serious is the interaction between Pramipexole and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation occurs. Advise patients not to drive for at least 12 hours after zuranolone and monitor for excessive sleepiness.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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