Drug interactions
Pravastatin + Rifampin
Severity: Moderate
Pravastatin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Single-dose rifampin can sharply raise pravastatin exposure, though chronic rifampin may have mixed effects through induction. The change can raise myopathy risk, and lipid control may vary.
What this interaction means in plain words
Pravastatin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Acute rifampin inhibits OATP1B1 hepatic uptake of pravastatin; chronic use may induce transporters and metabolism.
What to do
Monitor for muscle symptoms and lipid response during rifampin therapy, adjusting the pravastatin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Frequently asked questions
Can I take Pravastatin with Rifampin?
MediHelp rates the interaction as moderate. Pravastatin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Single-dose rifampin can sharply raise pravastatin exposure, though chronic rifampin may have mixed effects through induction. The change can raise myopathy risk, and lipid control may vary.
How serious is the interaction between Pravastatin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and lipid response during rifampin therapy, adjusting the pravastatin dose accordingly.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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