Drug interactions
Praziquantel + Ritonavir
Severity: Moderate
Praziquantel and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a potent CYP3A4 inhibitor and can raise praziquantel concentrations. This may increase dizziness, sedation, headache and gastrointestinal effects.
What this interaction means in plain words
Praziquantel and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Praziquantel belongs to Anti Parasitic; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir potently inhibits CYP3A4, decreasing first-pass and systemic clearance of praziquantel.
What to do
Monitor for praziquantel adverse effects and advise against driving after dosing. No routine dose reduction is needed for a short course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Praziquantel with Ritonavir?
MediHelp rates the interaction as moderate. Praziquantel and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a potent CYP3A4 inhibitor and can raise praziquantel concentrations. This may increase dizziness, sedation, headache and gastrointestinal effects.
How serious is the interaction between Praziquantel and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for praziquantel adverse effects and advise against driving after dosing. No routine dose reduction is needed for a short course.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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