Drug interactions
Prednisolone + Saxagliptin-metformin
Severity: Moderate
Prednisolone and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone raises blood glucose and can diminish the effect of saxagliptin and metformin. Significant hyperglycemia may occur with higher doses or longer courses.
What this interaction means in plain words
Prednisolone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisolone belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic glucose output and insulin resistance, opposing antidiabetic drugs.
What to do
Monitor blood glucose frequently during steroid therapy and adjust antidiabetic treatment, then reduce again as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Prednisolone with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Prednisolone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone raises blood glucose and can diminish the effect of saxagliptin and metformin. Significant hyperglycemia may occur with higher doses or longer courses.
How serious is the interaction between Prednisolone and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during steroid therapy and adjust antidiabetic treatment, then reduce again as the steroid is tapered.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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