Drug interactions
Prednisolone + Tolfenamic acid
Severity: Moderate
Prednisolone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a corticosteroid with an NSAID raises the risk of gastrointestinal ulceration and bleeding. The risk is greater with longer use, higher doses and advanced age.
What this interaction means in plain words
Prednisolone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisolone belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of protective prostaglandins combined with corticosteroid impairment of mucosal repair.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Prednisolone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Prednisolone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a corticosteroid with an NSAID raises the risk of gastrointestinal ulceration and bleeding. The risk is greater with longer use, higher doses and advanced age.
How serious is the interaction between Prednisolone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor. Monitor for signs of GI bleeding.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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