Drug interactions
Calcium + Radium-223 dichloride
Severity: Minor
Calcium and Radium-223 dichloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Radium-223 behaves like calcium and is taken up in areas of increased bone turnover. Calcium supplements might theoretically compete with it, though no clinically important effect has been demonstrated.
What this interaction means in plain words
Calcium and Radium-223 dichloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Radium-223 dichloride belongs to Miscellaneous.
Why it happens
Theoretical competition between calcium and radium for incorporation into bone mineral; not well established clinically.
What to do
Continue calcium when it is clinically needed, such as with bone-protective therapy; a brief pause before starting radium-223 is optional when supplementation is not essential.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Radium-223 dichloride
- Abiraterone + Radium-223 dichloride Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Radium-223 dichloride + Siponimod Moderate
- Radium-223 dichloride + Vitamin d Minor
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Radium-223 dichloride?
MediHelp rates the interaction as minor. Calcium and Radium-223 dichloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Radium-223 behaves like calcium and is taken up in areas of increased bone turnover. Calcium supplements might theoretically compete with it, though no clinically important effect has been demonstrated.
How serious is the interaction between Calcium and Radium-223 dichloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue calcium when it is clinically needed, such as with bone-protective therapy; a brief pause before starting radium-223 is optional when supplementation is not essential.
What other medicines interact with Radium-223 dichloride?
MediHelp also lists interactions of Radium-223 dichloride with, for example, Abiraterone, Prednisolone, Prednisone. The full list is on the Radium-223 dichloride page.
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