Drug interactions
Prednisone + Rocuronium
Severity: Moderate
Prednisone and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with non-depolarizing neuromuscular blockers, especially over prolonged periods in critically ill patients, are associated with acute myopathy and prolonged weakness. Steroids can also modify the response to the blocker.
What this interaction means in plain words
Prednisone and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Rocuronium belongs to Musculoskeletal.
Why it happens
Additive muscle injury and neuromuscular dysfunction; the exact mechanism is not fully defined.
What to do
Use the shortest effective duration of neuromuscular blockade and monitor with train-of-four. Evaluate for prolonged weakness and check creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Rocuronium
Frequently asked questions
Can I take Prednisone with Rocuronium?
MediHelp rates the interaction as moderate. Prednisone and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with non-depolarizing neuromuscular blockers, especially over prolonged periods in critically ill patients, are associated with acute myopathy and prolonged weakness. Steroids can also modify the response to the blocker.
How serious is the interaction between Prednisone and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective duration of neuromuscular blockade and monitor with train-of-four. Evaluate for prolonged weakness and check creatine kinase if myopathy is suspected.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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