Drug interactions
Prednisone + Somapacitan
Severity: Moderate
Prednisone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids can blunt the growth-promoting effect of growth hormone. Growth hormone also inhibits 11-beta-HSD1, which reduces conversion of cortisone and prednisone to active cortisol and prednisolone, so glucocorticoid replacement may become inadequate.
What this interaction means in plain words
Prednisone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism of growth hormone by glucocorticoids, and growth hormone inhibition of 11-beta-HSD1 that reduces activation of prednisone and cortisone.
What to do
Monitor growth and adrenal status, and adjust glucocorticoid doses as needed after starting somapacitan. Use the lowest effective glucocorticoid dose in growing children.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Prednisone with Somapacitan?
MediHelp rates the interaction as moderate. Prednisone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids can blunt the growth-promoting effect of growth hormone. Growth hormone also inhibits 11-beta-HSD1, which reduces conversion of cortisone and prednisone to active cortisol and prednisolone, so glucocorticoid replacement may become inadequate.
How serious is the interaction between Prednisone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth and adrenal status, and adjust glucocorticoid doses as needed after starting somapacitan. Use the lowest effective glucocorticoid dose in growing children.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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