Drug interactions
Prednisone + Sotorasib
Severity: Minor
Prednisone and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor, which could theoretically increase exposure to P-gp substrates. Prednisone and prednisolone are only modest P-gp substrates, so any change is unlikely to be clinically important.
What this interaction means in plain words
Prednisone and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prednisone belongs to Endocrine; Sotorasib belongs to Oncology.
Why it happens
Possible P-gp inhibition by sotorasib may slightly alter corticosteroid transport and absorption.
What to do
No routine adjustment is needed. Monitor for increased corticosteroid adverse effects if prednisone is used at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Prednisone with Sotorasib?
MediHelp rates the interaction as minor. Prednisone and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-gp inhibitor, which could theoretically increase exposure to P-gp substrates. Prednisone and prednisolone are only modest P-gp substrates, so any change is unlikely to be clinically important.
How serious is the interaction between Prednisone and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for increased corticosteroid adverse effects if prednisone is used at high doses.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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