Drug interactions
Prednisone + Trastuzumab
Severity: Moderate
Prednisone and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can contribute to infection risk in patients receiving chemotherapy; corticosteroids are immunosuppressive and trastuzumab with chemotherapy increases neutropenia. Corticosteroids are also frequently used as premedication for infusion reactions.
What this interaction means in plain words
Prednisone and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression-related infection risk; no direct pharmacokinetic interaction.
What to do
Monitor blood counts and for signs of infection during combined therapy. Use the lowest effective corticosteroid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Prednisone with Trastuzumab?
MediHelp rates the interaction as moderate. Prednisone and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can contribute to infection risk in patients receiving chemotherapy; corticosteroids are immunosuppressive and trastuzumab with chemotherapy increases neutropenia. Corticosteroids are also frequently used as premedication for infusion reactions.
How serious is the interaction between Prednisone and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection during combined therapy. Use the lowest effective corticosteroid dose.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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