Drug interactions
Primaquine + Salbutamol
Severity: Moderate
Primaquine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primaquine has been associated with QT prolongation, and salbutamol can add to arrhythmic risk through tachycardia and hypokalemia. The combination may be of concern in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Primaquine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a contributor.
What to do
Check ECG and potassium in patients with cardiac risk factors. Avoid excessive salbutamol dosing during primaquine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Primaquine with Salbutamol?
MediHelp rates the interaction as moderate. Primaquine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primaquine has been associated with QT prolongation, and salbutamol can add to arrhythmic risk through tachycardia and hypokalemia. The combination may be of concern in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Primaquine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium in patients with cardiac risk factors. Avoid excessive salbutamol dosing during primaquine therapy.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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