Drug interactions
Primaquine + Triptorelin
Severity: Moderate
Primaquine and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with triptorelin can prolong the QT interval, and primaquine may add to this effect. The combination may modestly raise the risk of arrhythmia.
What this interaction means in plain words
Primaquine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen deprivation therapy is associated with QT prolongation.
What to do
Check a baseline ECG and correct electrolyte disturbances. Reassess the combination if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Triptorelin
Frequently asked questions
Can I take Primaquine with Triptorelin?
MediHelp rates the interaction as moderate. Primaquine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with triptorelin can prolong the QT interval, and primaquine may add to this effect. The combination may modestly raise the risk of arrhythmia.
How serious is the interaction between Primaquine and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolyte disturbances. Reassess the combination if the QTc is prolonged.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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