Drug interactions
Primidone + Tranylcypromine
Severity: Moderate
Primidone and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is converted to phenobarbital, and MAOIs may prolong barbiturate effects. This could increase sedation and CNS depression.
What this interaction means in plain words
Primidone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Possible reduced barbiturate metabolism with additive CNS depression.
What to do
Monitor for sedation and ataxia when starting or changing either drug. Consider checking primidone and phenobarbital levels if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Tranylcypromine?
MediHelp rates the interaction as moderate. Primidone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is converted to phenobarbital, and MAOIs may prolong barbiturate effects. This could increase sedation and CNS depression.
How serious is the interaction between Primidone and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and ataxia when starting or changing either drug. Consider checking primidone and phenobarbital levels if toxicity occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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