Drug interactions
Primidone + Vinblastine
Severity: Moderate
Primidone and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly metabolized to phenobarbital, induces CYP3A4 and may reduce vinblastine exposure. This may compromise antitumor efficacy.
What this interaction means in plain words
Primidone and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Vinblastine belongs to Oncology.
Why it happens
Primidone and its phenobarbital metabolite induce CYP3A4, increasing vinblastine clearance.
What to do
Switch to a non-enzyme-inducing antiseizure drug such as levetiracetam where possible, in consultation with neurology. Otherwise monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Vinblastine?
MediHelp rates the interaction as moderate. Primidone and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly metabolized to phenobarbital, induces CYP3A4 and may reduce vinblastine exposure. This may compromise antitumor efficacy.
How serious is the interaction between Primidone and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Switch to a non-enzyme-inducing antiseizure drug such as levetiracetam where possible, in consultation with neurology. Otherwise monitor treatment response.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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