Drug interactions
Probenecid + Tolmetin
Severity: Moderate
Probenecid and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal tubular secretion of tolmetin and other NSAIDs, raising NSAID plasma concentrations and prolonging their half-life. This can increase the risk of NSAID adverse effects such as gastrointestinal and renal toxicity.
What this interaction means in plain words
Probenecid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Probenecid belongs to Genitourinary; Tolmetin belongs to Musculoskeletal.
Why it happens
Probenecid inhibits organic anion transporters in the renal tubule, decreasing tolmetin's renal clearance.
What to do
Monitor for NSAID adverse effects such as GI upset, bleeding and fluid retention, and use the lowest effective tolmetin dose. Consider reducing the tolmetin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Probenecid and Tolmetin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Tolmetin?
MediHelp rates the interaction as moderate. Probenecid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal tubular secretion of tolmetin and other NSAIDs, raising NSAID plasma concentrations and prolonging their half-life. This can increase the risk of NSAID adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Probenecid and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as GI upset, bleeding and fluid retention, and use the lowest effective tolmetin dose. Consider reducing the tolmetin dose if toxicity appears.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
