Drug interactions
Procainamide + Ribociclib
Severity: Major
Procainamide and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, and procainamide is a class IA antiarrhythmic associated with torsades de pointes. Together they increase the risk of life-threatening arrhythmia.
What this interaction means in plain words
Procainamide and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation via effects on cardiac repolarization.
What to do
Avoid the combination; if procainamide is essential, monitor ECG and electrolytes closely and withhold ribociclib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Procainamide with Ribociclib?
MediHelp rates the interaction as major. Procainamide and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QT interval, and procainamide is a class IA antiarrhythmic associated with torsades de pointes. Together they increase the risk of life-threatening arrhythmia.
How serious is the interaction between Procainamide and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if procainamide is essential, monitor ECG and electrolytes closely and withhold ribociclib if QTc becomes markedly prolonged.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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