Drug interactions
Procarbazine + Salbutamol
Severity: Moderate
Procarbazine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitor activity, which can potentiate sympathomimetic agents. Combined with salbutamol, this may cause excessive cardiovascular stimulation, including hypertensive reactions and tachycardia.
What this interaction means in plain words
Procarbazine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Salbutamol belongs to Respiratory.
Why it happens
Weak MAO inhibition by procarbazine enhances the pressor and cardiac effects of sympathomimetics.
What to do
Monitor blood pressure and heart rate when salbutamol is used, particularly at higher doses. Prefer inhaled over systemic salbutamol and counsel on symptoms of hypertensive crisis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Salbutamol?
MediHelp rates the interaction as moderate. Procarbazine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitor activity, which can potentiate sympathomimetic agents. Combined with salbutamol, this may cause excessive cardiovascular stimulation, including hypertensive reactions and tachycardia.
How serious is the interaction between Procarbazine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when salbutamol is used, particularly at higher doses. Prefer inhaled over systemic salbutamol and counsel on symptoms of hypertensive crisis.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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