Drug interactions
Procarbazine + Salmeterol
Severity: Moderate
Procarbazine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitor activity, and MAO inhibitors can potentiate the cardiovascular effects of beta-agonists. Salmeterol labeling advises caution with MAO inhibitors because of possible tachycardia, palpitations and blood pressure changes.
What this interaction means in plain words
Procarbazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
MAO inhibition may potentiate the adrenergic cardiovascular effects of salmeterol.
What to do
Monitor heart rate, blood pressure and arrhythmia symptoms when starting or continuing salmeterol. Consider a short-acting alternative if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Salmeterol?
MediHelp rates the interaction as moderate. Procarbazine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitor activity, and MAO inhibitors can potentiate the cardiovascular effects of beta-agonists. Salmeterol labeling advises caution with MAO inhibitors because of possible tachycardia, palpitations and blood pressure changes.
How serious is the interaction between Procarbazine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and arrhythmia symptoms when starting or continuing salmeterol. Consider a short-acting alternative if cardiovascular effects occur.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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