Drug interactions
Procarbazine + Siponimod
Severity: Moderate
Procarbazine and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is an alkylating agent that causes myelosuppression. Siponimod lowers lymphocyte counts, so the combination may increase the risk of serious infection.
What this interaction means in plain words
Procarbazine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: cytotoxic bone marrow suppression plus S1P-mediated lymphocyte reduction.
What to do
Monitor complete blood counts and for infection during co-therapy. Consider interrupting siponimod if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Siponimod?
MediHelp rates the interaction as moderate. Procarbazine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is an alkylating agent that causes myelosuppression. Siponimod lowers lymphocyte counts, so the combination may increase the risk of serious infection.
How serious is the interaction between Procarbazine and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection during co-therapy. Consider interrupting siponimod if marked myelosuppression occurs.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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